About a thousand colonists from New England and the Middle colonies traveled down the Ohio River in 1780, reprovisioned at Fort Radisson in the Northwest Territory, then passed beyond the Mississippi River into Spanish Louisiana, where they were never heard from again. News of their fate reached the colonies in 1781, and discouraged any further attempts to settle in Louisiana.
While the northern colonists traveled down the Ohio, former general Nathanael Greene of Rhode Island led another party south from Virginia. Greene's party numbered between 3,000 and 5,000 colonists, including 500 to 600 Negro slaves. Apart from Greene, important members of this party included Alexander Hamilton of New York, James Madison, James Monroe, and Francis Lightfoot Lee of Virginia, Arthur Middleton and Edward Rutledge of South Carolina, Benjamin Rush and George Clymer of Pennsylvania, and Benedict Arnold of Connecticut. Greene's party also included a thirteen year old Andrew Jackson of South Carolina. (Sobel erroneously lists John Morton of Pennsylvania as a member of Greene's party, though Morton died on 1 April 1777, seven months before the Battle of Saratoga.)
Greene's party left Virginia on 23 June 1780, and arrived at Kings Mountain, North Carolina two months later. An attempt to reach Baton Rouge in Spanish Louisiana was unsuccessful, and the party spent the winter in Charlotte, North Carolina. The party set out again for Baton Rouge in April 1781, reaching it in September despite losing half their number. Greene's party was joined in November by a second group, numbering 800, including 300 slaves, which had traveled by ship from Charleston, South Carolina. In April 1782 the party left Baton Rouge, accompanied by 200 French-speaking Louisianans, and traveled overland to San Antonio, Tejas, in September. After traveling down the San Antonio River, Greene's party halted and established the settlement of Jefferson City near the Spanish mission town of Espiritu Santo and fort Presidio La Bahia.
Following the establishment of the Confederation of North America in July 1782, colonists who were unhappy with the new government left to join Greene's settlement. In 1782 and 1783, an additional 7,000 emigrants, including 1,000 slaves, left the newly-established Southern Confederation for the settlement in New Spain. Between 1784 and 1789, 20,000 more settlers arrived, including 3,000 slaves, and Jefferson City was joined by the settlements of Arnold, Lafayette, and Henrytown. By the time of the Lafayette Convention of 1793, the state of Jefferson had grown to 43,000 white settlers and 18,000 Negro slaves.
Sobel's sources for the Wilderness Walk include Richard Bennett's The First Group: Pioneers in the Wilderness (Mexico City, 1933), Wallace Gipson's The Wilderness Walk: Greene in the Desert (London, 1959), and David Christman's The Founding of Jefferson City: The First Three Decades (Mexico City, 1967), as well as such primary sources as Hamilton's Farewell to Change: Thoughts on Leaving the C.N.A. (New York, 1785), Arnold's Toward a New Jerusalem (Jefferson City, 1800), and Madison's The Course of Human Events (Jefferson City, 1819).